金沙集团优惠申请大厅

金沙集团优惠申请大厅:分子病毒及疫苗研发研究组

 
组长:邓涛 博士、研究员

 

 

 

  研究组研究方向 

 

    流感病毒复制机制及抗病毒策略研发

 

 

  研究组研究内容

  

    1.流感病毒RNAs及RNA聚合酶复合体结构与功能,与宿主因子相互作用,选择性包装等分子机制研究

    2. 新型抗流感策略包括流感病毒疫苗及抗流感药物研发

 

 

  研究队伍

 

    研究组长:邓涛

    电话:64807980

    电子邮件:dengt#im.ac.cn(请将#替换成@)

    通讯地址:北京市朝阳区北辰西路1号院3号

    邮政编码:100101

  

  学习经历

    

    1988.09-1992.06 兰州大学生物系. 生物学 学士

    2002.11-2006.03 英国牛津大学病理系 分子病毒学 博士

 

  工作经历

 

    1992.06-2000.08 中国卫生部兰州生物制品研究所,助理研究员

    2001.04-2001.11 英国牛津大学邓肯病理学院,访问学者

    2001.11-2006.03 英国牛津大学邓肯病理学院,研究助理

    2006.04-2008.12 英国牛津大学邓肯病理学院,博士后

    2009.01-2009.10 英国国家生物制品标准与控制研究院,资深科学家

    2009.10-2020.03 中国医学科学院病原生物学研究所,研究员

    2020.03-至今 金沙集团优惠申请大厅病原室,研究员

 

 

 

  发表论文

    

  1. Gao S, Zhang W, Lu C, Cao M, Cen S, Peng Y, Deng T*. 2019. Identification of a type-specific promoter element that differentiates between influenza A and B viruses. J Virol., 93(23). doi: 10.1128/JVI.01164-19. 

  2. Peng Q, Liu Y, Peng R, Wang M, Yang W, Song H, Chen Y, Liu S, Han M, Zhang X, Wang P, Yan J, Zhang B, Qi J, Deng T, Gao GF, Shi Y. 2019. Structural insight into RNA synthesis by influenza D polymerase. Nat Microbiol., 4(10):1750-1759. doi: 10.1038/s41564-019-0487-5.  

  3. Wang J, Zhang Y, Li Q, Zhao J, Yi D, Ding J, Zhao F, Hu S, Zhou J, Deng T, Li X, Guo F, Liang C, Cen S. 2019. Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1. Cell Rep., 27(11). doi: 10.1016/j.celrep.2019.05.036. 

  4. Li C, Wang Z, Cao Y, Wang L, Ji J, Chen Z, Deng T, Jiang T, Cheng G, Qin FX. 2017. Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System. J Virol., 91(5). doi: 10.1128/JVI.02282-16. 

  5. Wang J, Li J, Zhao L, Cao M, Deng T*. 2017. Dual Roles of the Hemagglutinin Segment-Specific Noncoding Nucleotides in the Extended Duplex Region of the Influenza A Virus RNA Promoter. J Virol., 91(1). doi: 10.1128/JVI.01931-16.  

  6. Wang Z, Zhao F, Gao Q, Liu Z, Zhang Y, Li X, Li Y, Ma W, Deng T, Zhang Z, Cen S. 2015. Establishment of a High-Throughput Assay to Monitor Influenza A Virus RNA Transcription and Replication. PLoS One, 10(7). doi: 10.1371/journal.pone.0133558 

  7. Wang J, Peng Y, Zhao L, Cao M, Hung T, Deng T*. 2014. Influenza A virus Utilizes a Suboptimal Kozak Sequence to Fine-tune Virus Replication and Host Response. J Gen Virol., 96(Pt 4). doi: 10.1099/vir.0.000030. 

  8.  Li C, Wu A, Peng Y, Wang J, Guo Y, Chen Z, Zhang H, Wang Y, Dong J, Wang L, Qin FX, Cheng G, Deng T*, Jiang T*. 2014. Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein. Sci Rep., 26(4). doi: 10.1038/srep07192. 

  9. Cao M, Wei C, Zhao L, Wang J, Jia Q, Wang X, Jin Q, Deng T*. 2014. DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity. J Virol., 88(24), doi: 10.1128/JVI.02475-14.  

  10. Zhao L, Peng Y, Zhou K, Cao M, Wang J, Wang X, Jiang T, Deng T*. 2014. New Insights into the Nonconserved Noncoding Region of the Subtype-Determinant Hemagglutinin and Neuraminidase Segments of Inuenza A Viruses. J Virol., 88(19). doi: 10.1128/JVI.01337-14. 

  11. Zhou Z, Cao M, Guo Y, Zhao L, Wang J, Jia X, Li J, Wang C, Gabriel G, Xue Q, Yi Y, Cui S, Jin Q*, Wang J*, Deng T*. 2014. Fragile X mental retardation protein stimulates ribonucleoprotein assembly of Influenza A virus. Nat Commun., 5:3259. doi: 10.1038/ncomms4259. 

  12. Tefsen B,Lu G,Zhu Y,Haywood J,Zhao L, Deng T, Qi J,Gao GF. 2014. The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity. J. Virol.,88 (4). doi: 10.1128/JVI.03270-13. 

  13. Li C, Ba Q, Wu A, Zhang H, Deng T*, Jiang T*. 2013. A peptide derived from C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly. FEBS J., 280(4). doi: 10.1111/febs.12107. 

  14. Dreger M, Leung BW, Brownlee GG*, Deng T*. 2009. A quantitative proteomics strategy to detect protein regions affected by protein-protein interactions. Protein Science, 18(7). doi: 10.1002/pro.159. 

  15. Kashiwagi T, Leung BW, Deng T and Brownlee GG. 2009. The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) regulates promoter binding. PLos One, 4(5). doi: 10.1371/journal.pone.0005473. 

  16. Yuan P, Bartlam M, Lou Z, Chen S, Zhou J, He X, Lv Z, Ge R, Li X, Deng T, Fodor E, Rao Z & Liu Y. 2009. Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site. Nature, 458 (7240). doi: 10.1038/nature07720. 

  17. Chase G#, Deng T#, Fodor E, Mayer D, Schwemmle M and Brownlee GG .2006. Hsp90 inhibitors reduce influenza virus replication in cell culture. Virology, 377(2). doi: 10.1016/j.virol.2008.04.040. 

  18. Deng T#, Sharps J, Brownlee GG. 2006. The role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication. J Gen Virol., 87(Pt11): 3373-3377.  

  19. Deng T#, Engelhardt OG*, Thomas B, Akoulitchev AV, Brownlee GG and Fodor E. 2006. The role of Ran binding protein 5 (RanBP5) in the nuclear import and assembly of he influenza virus RNA polymerase complex. J Virol., 80:11911-11919. 

  20. Deng T#, Vreede FT#, Brownlee GG. 2006. Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication. J Virol., 80(5):2337-2348. 

  21. Deng T# Sharps J, Fodor E, Brownlee GG. 2005. In vitro assembly of PB2 with PB1-PA dimer supports a new model assembly of influenza A virus polymerase subunits into a functional trimeric complex. J Virol., 79(13):8669-8674. 

  22. Crow M#, Deng T#, Addley M, Brownlee GG. 2004. Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication. J Virol., 78(12):6263-6270.  

  23. Fodor E, Mingay LJ, Crow M, Deng T, Brownlee GG. 2003. A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs. J. Virol.,77(8):5017-5020.  

  24. Fodor E, Crow M, Mingay LJ, Deng T, Sharps J, Fechter P, Brownlee GG. 2002. A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs. J. Virol., 76(18):8989-9001.  

 

 

   已授权国家发明专利 

 

  1.    邓涛、郭阳、周卓。一种提高流感病毒疫苗株产量的方法,专利授权号ZL 2012 1 0299497.2, 授权日期:2015.08.05 

  2.    邓涛,赵丽丽。甲型流感病毒亚型基因型定型的方法,专利授权号ZL 2014 1 0354092.3 授权日期:2017.01.18 

       

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